1985 in Dallas, the homophobic electrician and rider Ron woodroof rodeo is a cocaine user who frequently have sex with prostitutes and promiscuous women. If he goes out of his trailer, he went to the hospital where Dr. Seward and Dr. Eve to tell him that he is HIV positive and will die within thirty days. Ron is also trans-genre Rayon, addicts and also has the disease. Ron does not agree with the diagnosis, but a few days later, he realizes that may be incorrect. He conducts research on the disease and shows that AZT is deadly to humans can be infected. In addition, it was found that in Mexico there is a doctor with license revoked called Reed to alternative drugs used to treat AIDS. Ron improves his health and decided to sell the drug in Dallas. It is collaboration with Rayon and soon created Dallas Buyers Club, where membership pays four hundred dollars a month to make the necessary medicines. But the FDA approves their research and suppressed by the authorities.